Protein Expression Market - Global Size, Share, Trends, Growth and Forecast Year ( 2022 – 2032 )

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Protein Expression Market Dynamics

Protein Expression Market by System Type (Mammalian cell expression systems, Prokaryotic expression systems, Insect cell expression systems, Yeast expression systems, Cell-free expression systems, Algal-based expression systems), Application (Therapeutic, Research, Industrial), End User( Pharmaceutical and Biotechnology companies,   Contract Research Organizations and Contract Development and Manufacturing Organizations (CROs and CDMOs), Academic Research Institutes, Other End Users) and Geographic Regions (North America, Europe, Asia Pacific, Latin America, Middle East and Africa): Industry Trends and Global Forecasts, 2023-2032.

Market Size and Overview:

The protein expression market has witnessed significant growth, with a steady compound annual growth rate (CAGR) of 11.4% from 2023 to 2032, reaching a market value of $8.5 billion in 2032. This growth can be attributed to the increasing demand for recombinant proteins in various research, diagnostic, and therapeutic applications. Additionally, advancements in genetic engineering and biotechnology have enabled the production of proteins with high efficiency and yield. The market comprises a wide range of products, including expression vectors, competent cells, reagents, and instruments. Key players in the market are continuously innovating to develop novel expression systems and improve protein production efficiency to meet the evolving needs of the industry.

Protein Expression Market: Report Scope

Base Year Market Size


Forecast Year Market Size


CAGR Value



  • By System Type
  • By Application
  • By End Users
  • By Geographic Regions


  • High cost
  • Lack of effective systems for post-translational modifications

Growth Drivers

  • There is an increasing demand for protein biologics in the treatment of chronic diseases
  • The occurrence of target illnesses
  • Rising investments in research and development activities
  • Government support for proteomics and genomics research


Market Segmentation:

System Type

  • Mammalian cell expression systems
  • Prokaryotic expression systems
  • Insect cell expression systems
  • Yeast expression systems
  • Cell-free expression systems
  • Algal-based expression systems


  • Therapeutic
  • Research
  • Industrial

End User

  • Pharmaceutical and Biotechnology companies
  • Contract Research Organizations and Contract Development and Manufacturing Organizations (CROs and CDMOs)
  • Academic Research Institutes
  • Other End Users

Geographic Regions:

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East and Africa

Cell-Free Expression Systems: The cell-free expression systems segment holds the largest market share in the protein expression market. This technology allows protein expression without the use of live cells, offering several advantages over other expression techniques. The industry is witnessing significant growth due to the widespread adoption of cell-free protein approaches, including enhanced speed, the ability to produce hazardous proteins, and the convenience of amino acid type-specific labeling. The versatility and flexibility of cell-free systems contribute to their popularity in various protein expression applications.

Therapeutic: The therapeutic segment is projected to account for a significant revenue share in the protein expression market. The increasing adoption of proteins in biologics production and the growing preference for protein therapies to treat chronic diseases, such as cancer, anemia, hemophilia, multiple sclerosis, arthritis, and diabetes, among others, drive the demand for protein expression technologies in the therapeutic field. Proteins are utilized as therapeutic agents due to their ability to specifically target disease-related molecules and exhibit high efficacy in disease treatment.

Regional Analysis:

North America, region emerged as the largest market for protein expression. The growth in the biotechnology and pharmaceutical industries, along with the increasing prevalence of chronic disorders, has contributed to the region's dominance. North America holds a significant share in the global market, driven by substantial investments in protein-based therapeutics research. The Asia Pacific region is expected to witness the fastest growth, during the forecast period. This rapid growth can be attributed to the significant developments in protein expression adoption by countries like India and China. The region showcases a growing focus on proteomics and genomics research, coupled with initiatives by academic institutions to drive innovative advancements in protein therapeutics. Latin America demonstrates steady growth in the Protein Expression Market, fueled by urban development, a rising middle class, and an increasing demand for protein-based therapies and biologics. Brazil, Mexico, and Argentina emerge as key markets within the region, with a growing emphasis on research and development activities in the field of protein expression. The Middle East and Africa exhibit a developing market with a focus on urban development, and an increasing emphasis on healthcare infrastructure. The United Arab Emirates, Saudi Arabia, and South Africa contribute significantly to the market's growth in this region.

Growth Drivers:

Several factors drive the growth of the protein expression market. Firstly, there is an increasing demand for protein biologics in the treatment of chronic diseases such as cancer, autoimmune diseases, and genetic disorders. Biologics, including vaccines, blood components, and recombinant therapeutic proteins, have shown remarkable efficacy in treating a wide range of illnesses. This rising demand for protein biologics is a significant driver of market growth.

Furthermore, the occurrence of target illnesses, such as cancer and cardiovascular diseases, is increasing, leading to a higher adoption rate of protein therapies. Protein-based medications, like insulin, have proven to be highly effective in treating various diseases, driving the growth of the protein expression system market.

Moreover, the rising investments in research and development activities in the pharmaceutical and biotechnology sectors propel market expansion. Increasing collaborations between academic institutions, research organizations, and industry players drive innovation and the adoption of protein expression technologies. Government support for proteomics and genomics research also acts as a market driver. Governments worldwide are providing support and funding for research initiatives in proteomics and genomics. This support encourages the development of protein expression systems and fosters innovation in the field.


The high cost of protein expression systems is a significant restraint. Additionally, there is a lack of effective systems for post-translational modifications, which may hinder the production of complex protein structures and functionalities.

Protein Expression Market 

Key Companies:

The Protein Expression Market is dominated by several leading companies like Thermo Fisher Scientific Inc., Merck KGaA, GenScript Biotech Corporation, Agilent Technologies Inc., Danaher Corporation, Sartorius AG, Takara Bio Inc., Bio-Rad Laboratories Inc., Lonza Group AG, Promega Corporation, New England Biolabs, and Oxford Expression Technologies Ltd. among other players. These companies have established a strong market presence, extensive distribution networks, and a diverse product portfolio. Their competitive strategies focus on product innovation, strategic partnerships, mergers, and acquisitions to enhance their market share and address the diverse needs of customers.

In June 2021, Thermo Fisher Scientific Inc. and Advanced Electrophoresis Solutions Ltd. (AES) entered into an agreement to combine protein separation techniques with mass spectrometry (MS) for improved characterization of therapeutic proteins. This collaboration aims to streamline the development of therapeutic proteins and advance research in the field.

in September 2021 when Aviva Systems Biology, a prominent provider of antibodies, immunoassay kits, and recombinant proteins for life science research, introduced its new Protein on Demand platform. This semi-custom recombinant protein portfolio caters to the needs of life scientists involved in basic research and preclinical studies.

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  • Publication date: 3rd September 2023
  • Base year: 2022
  • Forecast year: 2023-2033
  • Format: PDF, PPT,Word,Excel

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The market is primarily driven by the increasing demand for protein biologics, rising occurrence of target illnesses, and escalating research and development activity in the pharmaceutical sector.

The cell-free expression systems segment holds the largest market share in the protein expression market.

The Asia Pacific region showcases significant growth potential due to rapid economic growth, increasing investments in life sciences research, and a growing biopharmaceutical industry.

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