Bone Graft & Substitutes Market: Global Size, Share, Trends, Growth and Forecast, 2022-2032

Life Science

Request PDF Sample Request Discount
  • Status : Published
  • Published on: Feb 2022
  • Report ID: KDMI-4229
  • Available Format: PDF/Excel/DOC


Pandemic disrupted the entire world and affected many industries.

Get detailed COVID-19 impact analysis on the Bone Graft & Substitutes Market

Request PDF Sample

Bone grafts and substitutes are synthetic implantable materials, which are used for healing, repairing, formation, and osseous reconstruction of the missing or fractured bones or gum tissues in the body. They exhibit osteoconductive, osteogenic, osteoinductive and biocompatible natural properties and are known to relieve pain in the body. They are also bioresorbable in nature, cause no antigen-antibody reaction and are easy to use, safe, and cost-effective.

Bone grafts are soon replaced with the healing of natural bone which makes them highly desirable in wide range of applications including spinal fusion, sports, trauma, dental bone grafting, craniomaxillofacial, nerve repositioning, joint reconstruction, and other bone grafting procedures.

The bone grafts or substitutes may be derived from the patient’s own body, from a donor’s body or can also be engineered by using natural or synthetic materials such as ceramics and polymers.

The global bone graft and substitutes market is projected to expand at a CAGR of around 6.7% over the period of next 5 years.


The growth of this market is attributed towards major relying factors including; the growing incidences of bone and joint disorders across the globe, the rising demand and requirement for dental bone grafts and substitutes, the increasing number of replacement surgeries, the proliferating technological advancements in the medical field worldwide, the high adoption of minimally invasive surgeries, the  surging government initiatives offering low-cost medical services and subsidiaries and the increasing number of studies investigating the enhancement of bioactivity of bone graft substitutes etc.

Additionally, in the recent years, there have been enormous technological advancements in healthcare industry. The increase in emphasis of key players towards R&D activities and on creating new avenues for medical treatment has assisted in the growth of new technologies such as the introduction of rapid prototyping or 3D printing which aids in the fabrication of free-form biomaterial scaffolds for tissue regeneration and the advent of new polymer and ceramic products that have biologically superior characteristics etc. This increasing focus on developing and offering variety of innovative bone graft products for treating bone related disorders is aiding in the growth of the bone grafts and substitutes market profoundly.

Moreover, for the purpose of gaining a stronger market share, major players are being witnessed to be extensively investing in the development of biocompatible synthetic grafts these days. For instance, scientists at the Texas A&M University developed a new synthetic material- a biodegradable scaffold to fill the gaps for new bone growth to advance grafting treatments required by the people for treating bone defects and bone cancers. The McGill University on the other hand developed a biocompatible and toughened multilayered bone graft for the treatment of large bone defects. This growing launch of biocompatible synthetic grafts is expected to provide lucrative growth opportunities to the bone grafts and substitutes market.

Furthermore, other factors such as the growing prevalence of bone cancer in the world, the increasing adoption of allograft, the surging number of accidents and orthopedic problems, growing awareness among patients about the benefits of bone regeneration through biologics also boost the bone grafts and substitutes market growth. Alongside, the increasing per-capita disposable income, the rising global geriatric population and high morbidity rates in regions further contribute considerably in driving growth for this market.

However, factors such as the high cost of surgeries, the high number of concerns and ethical issues associated with bone grafting procedures, the side effects of these products and the various deceptive marketing methods in use restrict the bone grafts and substitutes market growth.


By Material Type:

  • Allografts
    • Machined Allografts
    • Demineralized Bone Matrix (DBMs)
  • Bone Graft Substitutes
    • Bone Morphogenic Proteins (BMPs)
    • Synthetic Bone Grafts
  • Cell-based Matrices
  • Others

By Application:

  • Craniomaxillofacial
  • Dental Bone Grafting
  • Foot & Ankle
  • Trauma
  • Joint Reconstruction
  • Long Bone
  • Spinal Fusion

By End User:

  • Hospitals
  • Surgical Centers
  • Clinics
  • Others

By Region:

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa


The North American region is the dominant region in the bone grafts and substitutes market followed by Europe. The region is set to experience massive upscale in growth in the upcoming years and continue to stay at the topmost position. The growth in the region can be attributed to various factors such as; the proliferating number of trauma-related injuries as well as cases of orthopedic disease in the region, the growing awareness regarding innovative products in the region, the presence of advanced healthcare infrastructure in the region, the improving reimbursement facilities in the region along with growing investments in R&D activities, the presence of key players in this region and the increasing number of joint and spinal reconstruction surgeries in the region. The U.S is the major contributor to this region.

The Asia Pacific region has emerged as the fastest growing regional market for bone grafts and substitutes and this trend is expected to continue in the forthcoming years also. The growth in this region could be attributed to factors such as the increasing medical tourism in the region, the growing number of favorable initiatives by the government of major economies in the region, the rising adoption of bone grafts and substitutes in grafting modalities in the region and the development of novel bone graft substitutes that are efficient and affordable in the region. Furthermore, other factors such as the growing geriatric population, the increasing expenditure on healthcare expenses and the increasing presence of key market players in the region also contribute significantly to the growth of the market in this region. The major contributors in the region include India, Japan and China.


  • Johnson & Johnson (DePuy Synthes)
  • Medtronic Plc.
  • Musculoskeletal Transplant Foundation
  • Zimmer Biomet Holdings Inc.
  • ACE Surgical Supply Company Inc.
  • BioHorizons
  • Dentium
  • Dentsply Sirona
  • Nuvasive Inc.
  • Smith & Nephew
  • Orthofix Holdings Inc.
  • TBF Tissue Engineering
  • Wright Medical Group N.V.
  • Geistlich Pharma AG
  • Stryker Corporation
  • Biobank
  • Arthrex Inc.
  • Baxter International Inc.
  • Integra LifeSciences Holdings Corporation
  • Institut Straumann AG
  • AlloSource Inc.
  • Other Players


  • In November 2020, Karolinska Development AB announced that its portfolio company OssDsign acquired the bone graft substitute company Sirakoss Ltd.
  • In January 2021, Bioventus, a Durham biotech company that makes treatments for knee and joint pain filed plans to go public on the Nasdaq stock exchange — a move that could net the company $100 million. Bioventus, founded in 2011, has several products that treat issues like joint pain, such as the injectable treatments Durolane and Gelsyn-3. The company also makes bone graft substitutes that are used in surgeries.

Custom Research Requirement? Questions to ask?

Get in touch

Custom Research requirement.

Go Up